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Adiponitrile
CASRN 111-69-3
Contents
0515
Adiponitrile; CASRN 111-69-3
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Adiponitrile
File On-Line 02/01/1991
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) no data
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) on-line 02/01/1991
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Adiponitrile
CASRN -- 111-69-3
Not available at this time.
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Adiponitrile
CASRN -- 111-69-3
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Adiponitrile
CASRN -- 111-69-3
Last Revised -- 02/01/1991
Section II provides information on three aspects of the carcinogenic
assessment for the substance in question; the weight-of-evidence judgment of
the likelihood that the substance is a human carcinogen, and quantitative
estimates of risk from oral exposure and from inhalation exposure. The
quantitative risk estimates are presented in three ways. The slope factor is
the result of application of a low-dose extrapolation procedure and is
presented as the risk per (mg/kg)/day. The unit risk is the quantitative
estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m
air breathed. The third form in which risk is presented is a drinking water
or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1
in 1,000,000. The rationale and methods used to develop the carcinogenicity
information in IRIS are described in The Risk Assessment Guidelines of 1986
(EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries
developed since the publication of EPA's more recent Proposed Guidelines for
Carcinogen Risk Assessment also utilize those Guidelines where indicated
(Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to
Section I of this IRIS file for information on long-term toxic effects other
than carcinogenicity.
__II.A. EVIDENCE FOR CLASSIFICATION AS TO HUMAN CARCINOGENICITY
___II.A.1. WEIGHT-OF-EVIDENCE CLASSIFICATION
Classification -- D; not classifiable as to human carcinogenicity
Basis -- No human and no animal cancer data were available. Adiponitrile was
negative for mutagenicity in Salmonella with and without activation.
___II.A.2. HUMAN CARCINOGENICITY DATA
None.
___II.A.3. ANIMAL CARCINOGENICITY DATA
None.
___II.A.4. SUPPORTING DATA FOR CARCINOGENICITY
NIOSH (1978) reported that adiponitrile was negative for mutations in
several strains of Salmonella at concentrations up to 10,000 ug/plate in the
presence and absence of hepatic homogenates.
__II.B. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM ORAL EXPOSURE
None.
__II.C. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM INHALATION EXPOSURE
None.
__II.D. EPA DOCUMENTATION, REVIEW, AND CONTACTS (CARCINOGENICITY ASSESSMENT)
___II.D.1. EPA DOCUMENTATION
Source Document -- U.S. EPA, 1987
The 1987 Health and Environmental Effects Document on Adiponitrile has
received external peer review and Agency review.
___II.D.2. REVIEW (CARCINOGENICITY ASSESSMENT)
Agency Work Group Review -- 11/07/1990
Verification Date -- 11/07/1990
___II.D.3. U.S. EPA CONTACTS (CARCINOGENICITY ASSESSMENT)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
_VI. BIBLIOGRAPHY
Substance Name -- Adiponitrile
CASRN -- 111-69-3
Last Revised -- 02/01/1991
__VI.A. ORAL RfD REFERENCES
None
__VI.B. INHALATION RfC REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
NIOSH (National Institute for Occupational Safety and Health). 1978.
Criteria for a Recommended Standard...Occupational Exposure to Nitriles.
U.S. Dept. Health, Education and Welfare, Rockville, MD. NTIS PB 81-225534.
p. 166.
U.S. EPA. 1987. Health and Environmental Effects Document for Adiponitrile.
Prepared by the Office of Health and Environmental Assessment, Environmental
Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste
and Emergency Response, Washington, DC.
_VII. REVISION HISTORY
Substance Name -- Adiponitrile
CASRN -- 111-69-3
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
02/01/1991 II. Carcinogenicity assessment on-line
02/01/1991 VI. Bibliography on-line
VIII. SYNONYMS
Substance Name -- Adiponitrile
CASRN -- 111-69-3
Last Revised -- 02/01/1991
111-69-3
Hexanedinitrile
ADIPIC ACID DINITRILE
ADIPIC ACID NITRILE
Adipodinitrile
Adiponitrile
Adiponitrilo [Spanish]
Hexanedinitrile
HEXANEDIOIC ACID, DINITRILE
HSDB 627
NITRILE ADIPICO [Italian]
NSC 7617
Tetramethylene cyanide
UN 2205
1,4-DICYANOBUTANE
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0515.HTM
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