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p-Bromodiphenyl ether
CASRN 101-55-3
Contents
0490
p-Bromodiphenyl ether; CASRN 101-55-3
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR p-Bromodiphenyl ether
File On-Line 08/01/1990
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) no data
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) on-line 08/01/1990
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- p-Bromodiphenyl ether
CASRN -- 101-55-3
Not available at this time.
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- p-Bromodiphenyl ether
CASRN -- 101-55-3
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- p-Bromodiphenyl ether
CASRN -- 101-55-3
Last Revised -- 08/01/1990
Section II provides information on three aspects of the carcinogenic
assessment for the substance in question; the weight-of-evidence judgment of
the likelihood that the substance is a human carcinogen, and quantitative
estimates of risk from oral exposure and from inhalation exposure. The
quantitative risk estimates are presented in three ways. The slope factor is
the result of application of a low-dose extrapolation procedure and is
presented as the risk per (mg/kg)/day. The unit risk is the quantitative
estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m
air breathed. The third form in which risk is presented is a drinking water
or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1
in 1,000,000. The rationale and methods used to develop the carcinogenicity
information in IRIS are described in The Risk Assessment Guidelines of 1986
(EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries
developed since the publication of EPA's more recent Proposed Guidelines for
Carcinogen Risk Assessment also utilize those Guidelines where indicated
(Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to
Section I of this IRIS file for information on long-term toxic effects other
than carcinogenicity.
__II.A. EVIDENCE FOR CLASSIFICATION AS TO HUMAN CARCINOGENICITY
___II.A.1. WEIGHT-OF-EVIDENCE CLASSIFICATION
Classification -- D, not classifiable as to human carcinogenicity
Basis -- No human data and inadequate animal data.
___II.A.2. HUMAN CARCINOGENICITY DATA
None.
___II.A.3. ANIMAL CARCINOGENICITY DATA
Inadequate. No long-term animal studies of carcinogenicity are available.
Theiss et al. (1977) tested 4-bromodiphenyl ether in a short-term lung
adenoma test in strain A/St male mice (6 to 8 weeks old). Twenty mice/group
were injected intraperitoneally with 0, 40, 100, or 200 mg/kg of 4-
bromodiphenyl ether in tricaprylin 3 times/week for a total of 17 to 24
injections (total doses were 0, 920, 1700, and 3600 mg/kg, respectively).
Controls received the vehicle. There was no effect of treatment on survival.
Twenty-four weeks after the first injection, the mice were sacrificed and the
lungs examined for surface adenomas. The number of pulmonary tumors per mouse
was not elevated in treated animals relative to the vehicle controls. This is
generally regarded as a short-term in vivo screening bioassay for lung tumors.
___II.A.4. SUPPORTING DATA FOR CARCINOGENICITY
Treatment of CD-1 mice with 4-bromodiphenyl ether at doses ranging from
58 to 579 mg/kg/day by gavage for 14 days did not induce sister chromatid
exchanges (SCE) (Borzelleca, 1982).
4-Bromodiphenyl ether is structurally-related to decabromodiphenyl ether,
a possible human carcinogen.
__II.B. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM ORAL EXPOSURE
None.
__II.C. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM INHALATION EXPOSURE
None.
__II.D. EPA DOCUMENTATION, REVIEW, AND CONTACTS (CARCINOGENICITY ASSESSMENT)
___II.D.1. EPA DOCUMENTATION
Source Document -- U.S. EPA, 1986
The 1986 Health and Environmental Effects Profile for 4-Bromophenyl Phenyl
Ether has received Agency review.
___II.D.2. REVIEW (CARCINOGENICITY ASSESSMENT)
Agency Work Group Review -- 06/15/1990
Verification Date -- 06/15/1990
___II.D.3. U.S. EPA CONTACTS (CARCINOGENICITY ASSESSMENT)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
_VI. BIBLIOGRAPHY
Substance Name -- p-Bromodiphenyl ether
CASRN -- 101-55-3
Last Revised -- 08/01/1990
__VI.A. ORAL RfD REFERENCES
None
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
Borzelleca, J.F. 1982. A review of volatile organic contaminant data.
Proc. AWWA Water Qual. Tech. Conf. p. 225-244.
Thiess, J.C., G.D. Stoner, M.B. Shimkin and E.K. Weisburger. 1977. Test for
carcinogenicity of organic contaminants of United States drinking waters by
pulmonary tumor response in Strain A mice. Cancer Res. 37: 2717-2720.
U.S. EPA. 1986. Health and Environmental Effects Profile for 4-Bromophenyl
phenyl ether. Prepared by Environmental Criteria and Assessment Office,
Cincinnati, OH for the Office of Solid Waste and Emergency Response,
Washington, DC.
_VII. REVISION HISTORY
Substance Name -- p-Bromodiphenyl ether
CASRN -- 101-55-3
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
08/01/1990 II. Carcinogen assessment on-line
08/01/1990 VI. Bibliography on-line
01/01/1992 IV. Regulatory Action section on-line
VIII. SYNONYMS
Substance Name -- p-Bromodiphenyl ether
CASRN -- 101-55-3
Last Revised -- 08/01/1990
101-55-3
BENZENE, 1-BROMO-4-PHENOXY-
4-BROMODIPHENYL ETHER
1-BROMO-4-PHENOXYBENZENE
4-BROMOPHENOXYBENZENE
4-BROMOPHENYL PHENYL ETHER
DIPHENYL ETHER, 4-BROMO-
ETHER, 4-BROMOPHENYL PHENYL
ETHER, P-BROMOPHENYL PHENYL
HSDB 2747
NSC 5619
P-BROMODIPHENYL ETHER
P-BROMOPHENOXYBENZENE
P-BROMOPHENYL PHENYL ETHER
PHENYL ETHER, 4-BROMO-
P-PHENOXYBROMOBENZENE
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0490.HTM
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