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Acenaphthylene
CASRN 208-96-8
Contents
0443
Acenaphthylene; CASRN 208-96-8
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Acenaphthylene
File On-Line 01/01/1991
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) no data
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) on-line 01/01/1991
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Acenaphthylene
CASRN -- 208-96-8
Not available at this time.
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Acenaphthylene
CASRN -- 208-96-8
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Acenaphthylene
CASRN -- 208-96-8
Last Revised -- 01/01/1991
Section II provides information on three aspects of the carcinogenic
assessment for the substance in question; the weight-of-evidence judgment of
the likelihood that the substance is a human carcinogen, and quantitative
estimates of risk from oral exposure and from inhalation exposure. The
quantitative risk estimates are presented in three ways. The slope factor is
the result of application of a low-dose extrapolation procedure and is
presented as the risk per (mg/kg)/day. The unit risk is the quantitative
estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m
air breathed. The third form in which risk is presented is a drinking water
or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1
in 1,000,000. The rationale and methods used to develop the carcinogenicity
information in IRIS are described in The Risk Assessment Guidelines of 1986
(EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries
developed since the publication of EPA's more recent Proposed Guidelines for
Carcinogen Risk Assessment also utilize those Guidelines where indicated
(Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to
Section I of this IRIS file for information on long-term toxic effects other
than carcinogenicity.
__II.A. EVIDENCE FOR CLASSIFICATION AS TO HUMAN CARCINOGENICITY
___II.A.1. WEIGHT-OF-EVIDENCE CLASSIFICATION
Classification -- D; not classifiable as to human carcinogenicity
Basis -- Based on no human data and inadequate data from animal bioassays.
___II.A.2. HUMAN CARCINOGENICITY DATA
None.
___II.A.3. ANIMAL CARCINOGENICITY DATA
Inadequate. No tumors were observed in a lifetime study, when 0.25%
acenaphthylene (purity not specified) was applied to the skin (dose, frequency
and duration not stated) of mice (sex and strain not specified) (Cook, 1932).
Survival was 65% at 6 months, and 35% at 1 year. It is not stated whether a
control group was used. In the series of experiments, however, the dermal
application of other polycyclic aromatic hydrocarbons did result in the
formation of mouse skin tumors.
___II.A.4. SUPPORTING DATA FOR CARCINOGENICITY
Acenaphthylene (1 mM) yielded positive results in a Salmonella typhimurium
forward mutation assay (Kaden et al., 1979) and was not positive in a
Salmonella typhimurium TA98 and TA100 in the presence of hepatic homogenates
(Bos et al., 1988).
__II.B. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM ORAL EXPOSURE
None.
__II.C. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM INHALATION EXPOSURE
None.
__II.D. EPA DOCUMENTATION, REVIEW, AND CONTACTS (CARCINOGENICITY ASSESSMENT)
___II.D.1. EPA DOCUMENTATION
Source Document -- U.S. EPA, 1990
The 1990 Drinking Water Criteria Document for Polycyclic Aromatic Hydrocarbons
has received Agency and external review.
___II.D.2. REVIEW (CARCINOGENICITY ASSESSMENT)
Agency Work Group Review -- 02/07/1990
Verification Date -- 02/07/1990
___II.D.3. U.S. EPA CONTACTS (CARCINOGENICITY ASSESSMENT)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
_VI. BIBLIOGRAPHY
Substance Name -- Acenaphthylene
CASRN -- 208-96-8
Last Revised -- 01/01/1991
__VI.A. ORAL RfD REFERENCES
None
__VI.B. INHALATION RfC REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
Bos, R.P., J.L.G. Theuws, F.J. Jongeneelen and P.Th. Henderson. 1988.
Mutagenicity of bi-, tri-, and tetra-cyclic aromatic hydrocarbons in the
"taped-plate assay" and in the conventional Salmonella mutagenicity assay.
Mutat. Res. 204: 203-206.
Cook, J.W. 1932. The production of cancer by pure hydrocarbons -- Part II.
Proc. Royal Soc. London S.B. 11: 485-496.
Kaden, D.A., R.A. Hites and W.G. Thilly. 1979. Mutagenicity of soot and
associated polycyclic aromatic hydrocarbons to Salmonella typhimurium. Cancer
Res. 39: 4152-4159.
U.S. EPA. 1990. Drinking Water Criteria Document for Polycyclic Aromatic
Hydrocarbons (PAHs). Prepared by the Office of Health and Environmental
Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for
the Office of Drinking Water, Washington, DC. (Final Draft)
_VII. REVISION HISTORY
Substance Name -- Acenaphthylene
CASRN -- 208-96-8
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
01/01/1991 II. Carcinogen assessment on-line
01/01/1991 VI. Bibliography on-line
01/01/1992 IV. Regulatory Action section on-line
VIII. SYNONYMS
Substance Name -- Acenaphthylene
CASRN -- 208-96-8
Last Revised -- 01/01/1991
208-96-8
Acenaphthylene
Cyclopenta(de)naphthalene
HSDB 2661
NSC 59821
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0443.HTM
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