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Biphenthrin
CASRN 82657-04-3
Contents
0333
Biphenthrin; CASRN 82657-04-3
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Biphenthrin
File On-Line 08/22/1988
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 08/22/1988
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Biphenthrin
CASRN -- 82657-04-3
Primary Synonym -- Talstar
Last Revised -- 08/22/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Tremors NOEL: 1.5 mg/kg/day 100 1 1.5E-2
mg/kg/day
1-Year Dog Feeding LEL: 3.0 mg/kg/day
Study
FMC Corporation, 1985
*Conversion Factors: 1 ppm = 0.025 mg/kg/day (assumed dog food consumption)
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
FMC Corporation. 1985. Accession No. 264637. Available from EPA. Write to
FOI, EPA, Washington, DC 20460.
Beagle dogs (23 to 29 weeks of age; 4 dogs/sex/dose) were administered
biphenthrin in the diet at concentrations of 0 (Group 1), 0.75 (Group 2), 1.5
(Group 3), 3.0 (Group 4), and 5.0 (Group 5) mg/kg/day for 52 weeks. Animals
were inspected daily for appearance, behavior, appetite, and fecal elimination
and twice daily for signs of toxicity and mortality. The findings of note
include tremors in groups 4 and 5. Tremors were intermittent in one male and
two females of group 4 between weeks 15 and 23. All group 5 dogs displayed
tremors between weeks 15 and 29. Males appeared to display a greater
incidence of tremors. Tremors did not persist past week 29. No other
treatment-related effects were noted.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 100 was used, 10 each to account for the inter-
and intraspecies differences.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
The NOELs for developmental effects in rats are lower than the NOEL chosen to
establish the RfD. However, it is concluded that the RfD is sufficiently low
to account for developmental effects, providing a significant margin of
safety. Furthermore, the teratology study used dosing by gavage, which does
not reflect dietary exposure.
Data Considered for Establishing the RfD
1) 1-Year Feeding - dog: Principal study - see previous description; core
grade minimum
2) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=50 ppm (2.5 mg/kg/day);
Systemic LEL=100 ppm (5 mg/kg/day) (tremors, elevated body weight, higher but
statistically significant liver and kidney organ-to-body weight ratios); core
grade minimum (FMC Corp., 1986a)
3) 2-Generation Reproduction - rat: Maternal NOEL=30 ppm (1.5 mg/kg/day);
Maternal LEL=60 ppm (3 mg/kg/day) (lower but statistically significant mean
body weights of P1 and F1 females); Reproduction and Fetotoxic NOEL=100 ppm (5
mg/kg/day); Reproduction and Fetotoxic LEL=none; core grade minimum (FMC
Corp., 1986b)
4) Teratology - rat: Maternal NOEL=1 mg/kg/day; Maternal LEL=2 mg/kg/day
(HDT; tremors); Fetotoxic NOEL=1 mg/kg/day; Fetotoxic LEL=2 mg/kg/day (HDT;
increased incidence of hydroureter without hydronephrosis, an equivocal
finding); Teratogenic NOEL=2 mg/kg/day (HDT); Teratogenic LEL=none; core grade
minimum (FMC Corp., 1984a)
5) Teratology - rabbit: Maternal NOEL=2.67 mg/kg/day; Maternal LEL=4
mg/kg/day (head and forelimb twitching); Fetotoxic and Teratogenic NOEL=8
mg/kg/day (HDT); Fetotoxic and Teratogenic LEL=none; core grade minimum (FMC
Corp., 1984b)
Other Data Reviewed:
1) 13-Week Feeding - dog: NOEL=2.21 mg/kg/day; LEL=4.42 mg/kg/day (tremors);
core grade minimum (FMC Corp., 1984c)
2) 90-Day Feeding - rat: NOEL=50 ppm (2.5 mg/kg/day); LEL=100 ppm (5
mg/kg/day) (tremors in some males and females during first 16 days); core
grade minimum (FMC Corp., 1984d)
Data Gap(s): None
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- Medium
Data Base -- High
RfD -- High
The critical study is of adequate quality and is given a medium confidence
rating. The data base is given a high confidence rating due to the
similarities of NOELs in the supporting data. High confidence in the RfD
follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Source Document -- This assessment is not presented in any existing U.S. EPA
document.
Other EPA Documentation -- Pesticide Registration Files
Agency Work Group Review -- 02/25/1988, 05/25/1988, 07/20/1988
Verification Date -- 07/20/1988
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Biphenthrin
CASRN -- 82657-04-3
Primary Synonym -- Talstar
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Biphenthrin
CASRN -- 82657-04-3
Primary Synonym -- Talstar
Not available at this time.
_VI. BIBLIOGRAPHY
Substance Name -- Biphenthrin
CASRN -- 82657-04-3
Primary Synonym -- Talstar
Last Revised -- 10/01/1989
__VI.A. ORAL RfD REFERENCES
FMC Corporation. 1985. EPA Accession No. 264637. Available from EPA. Write
to FOI, EPA, Washington D.C. 20460.
FMC Corporation. 1986a. EPA Accession No. 26194042, 26194447. Available
from EPA. Write to FOI, EPA, Washington D.C. 20460.
FMC Corporation. 1986b. EPA Accession No. 26193335, 26193739. Available
from EPA. Write to FOI, EPA, Washington D.C. 20460.
FMC Corporation. 1984a. EPA Accession No. 254409. Available from EPA.
Write to FOI, EPA, Washington D.C. 20460.
FMC Corporation. 1984b. EPA Accession No. 254410. Available from EPA.
Write to FOI, EPA, Washington D.C. 20460.
FMC Corporation. 1984c. EPA Accession No. 254408. Available from EPA.
Write to FOI, EPA, Washington D.C. 20460.
FMC Corporation. 1984d. EPA Accession No. 254407. Available from EPA.
Write to FOI, EPA, Washington D.C. 20460.
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Biphenthrin
CASRN -- 82657-04-3
Primary Synonym -- Talstar
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
08/22/1988 I.A. Oral RfD summary on-line
10/01/1989 VI. Bibliography on-line
VIII. SYNONYMS
Substance Name -- Biphenthrin
CASRN -- 82657-04-3
Primary Synonym -- Talstar
Last Revised -- 08/22/1988
82657-04-3
Biphenthrin
brigade
cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-
dimethyl-,(2-methyl(1,1'-biphenyl)-3-yl)methyl ester, (z)-
FMC 54800
Talstar
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0333.HTM
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