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Ally
CASRN 74223-64-6
Contents
0288
Ally; CASRN 74223-64-6
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Ally
File On-Line 06/30/1988
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 06/30/1988
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Ally
CASRN -- 74223-64-6
Last Revised -- 06/30/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Decreased body NOEL: 500 ppm (25 100 1 2.5E-1
weight mg/kg/day) mg/kg/day
2-Year Rat Feeding/ LEL: 5000 ppm (250
Oncogenicity Study mg/kg/day)
duPont, 1985a
*Conversion Factors: 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
E.I. duPont de Nemours and Company, Inc. 1985a. MRID No. 00125931, 00151029,
00154477. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Groups of 90 male and 90 female Sprague-Dawley rats were fed diets containing
the test material at levels of 0, 5, 25, 500, or 5000 ppm for 2 years. Twenty
animals/sex/group were removed from the chronic study at 11 weeks for the
reproductive phase of the study and put back into the chronic phase at week
32. The LEL for systemic chronic toxicity is considered to be 5000 ppm based
on body weights. The NOEL has been determined to be 500 ppm.
Groups of 19 or 20 female rabbits were administered 2 mL portions of ally in
0.5% aqueous methocel by gavage during days 6 to 18 of gestation, at doses of
either 25, 100, 300, or 700 mg/kg/day. Developmental toxicity was not
demonstrated. Maternal toxicity was shown by a dose-related increase in
mortality and decrease in body weight at doses of 100 mg/kg/day or higher.
The 25 mg/kg/day dose was a NOEL. These results are consistent with those of
the primary study.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 100 was used to account for the inter- and
intraspecies differences.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
Data Considered for Establishing the RfD:
1) 2-Year Feeding (oncogenic) - rat: Principal study - see previous
description; core grade minimum
2) 1-Year Feeding - dog: NOEL=5000 ppm (125 mg/kg/day) (no effect at the
HDT); core grade minimum (duPont, 1984)
3) 2-Generation Reproduction - rat: Maternal NOEL=500 ppm (25 mg/kg/day);
Maternal LEL=5000 ppm (250 mg/kg/day) (decreased weight gain); Reproductive
NOEL=5000 ppm (HDT); Fetotoxic NOEL=5000 ppm (HDT); core grade minimum
(duPont, 1985b)
4) Teratology - rat: Teratogenic NOEL=1000 mg/kg/day (HDT); Fetotoxic
NOEL=1000 mg/kg/day; Maternal toxic NOEL=none; Maternal toxic LEL=40 mg/kg/day
(hyperactivity, ungroomed coat); core grade minimum (duPont, 1982)
5) Teratology - rabbit: Maternal toxic NOEL=25 mg/kg/day; Maternal toxic
LEL=100 mg/kg/day (decreased weight gain and death); Teratogenic NOEL=700
mg/kg/day; Fetotoxic NOEL=700 mg/kg/day (HDT); core grade minimum (duPont,
1985c)
Data Gap(s): None
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- High
Data Base -- High
RfD -- High
The critical study is of good quality and and is given a high confidence
rating. Additional studies are also of good quality; therefore, the data base
is given a high confidence rating. High confidence in the RfD follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Source Document -- This assessment is not presented in any existing U.S. EPA
document.
Other EPA Documentation -- Pesticide Registration Files
Agency Work Group Review -- 04/22/1986, 08/12/1987
Verification Date -- 08/12/1987
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Ally
CASRN -- 74223-64-6
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Ally
CASRN -- 74223-64-6
This substance/agent has not undergone a complete evaluation and determination
under US EPA's IRIS program for evidence of human carcinogenic potential.
_VI. BIBLIOGRAPHY
Substance Name -- Ally
CASRN -- 74223-64-6
Last Revised -- 11/01/1989
__VI.A. ORAL RfD REFERENCES
E.I. duPont de Nemours and Company, Inc. 1982. MRID No. 00125835. Available
from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1984. MRID No. 00141821. Available
from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1985a. MRID No. 00125931, 00151029,
00154477. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1985b. MRID No. 00151028.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1985c. MRID No. 00151028.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Ally
CASRN -- 74223-64-6
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
11/01/1989 VI. Bibliography on-line
VIII. SYNONYMS
Substance Name -- Ally
CASRN -- 74223-64-6
Last Revised -- 06/30/1988
74223-64-6
Ally
Benzoic acid, 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)- carbonyl)
amino)sulfonyl)-, methyl ester
Benzoic acid, 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)
amino)sulfonyl)-, methyl ester (9CI)
Caswell No. 419H
DPD 63760M
DPX 6376
DPX T6376
EPA Pesticide Chemical Code 122010
Gropper
Methyl-2-((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)
sulfonyl)benzoate
Metsulfuron-methyl
Metsulfuron methyl ester [ANSI]
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0288.HTM
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