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Bidrin
CASRN 141-66-2
Contents
0211
Bidrin; CASRN 141-66-2
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Bidrin
File On-Line 09/30/1987
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 11/01/1989
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Bidrin
CASRN -- 141-66-2
Last Revised -- 11/01/1989
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Decreased pup NOEL: 2 ppm diet 1000 1 1E-4
survival (0.1 mg/kg/day) mg/kg/day
3-Generation Rat LEL: 5 ppm diet
Reproduction Study (0.25 mg/kg/day)
Shell Chemical, 1965a
*Conversion Factors: 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
Shell Chemical Company. 1965a. MRID No. 00013446, 00066340. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Bidrin was dissolved in water and mixed with powdered rat food to produce
concentrations of 2, 5, 15, and 50 ppm. The study was conducted in two parts.
In part one, weanling Long-Evans rats were assigned (10 males and 20 females)
to groups receiving 0, 5, 15, or 50 ppm bidrin. In part two, weanling Long-
Evans rats were assigned (10 males and 20 females) to groups receiving 0 and 2
ppm bidrin. Sections of brain, heart, lung, liver, spleen, pancreas, kidney,
and testes were preserved for histologic examination. Reproductive toxicity
(decreased pup survival) was observed at 5 ppm. Other effects (weakness,
emaciation, and CNS effects) were seen at 50 ppm. No effects were observed at
2 ppm.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 1000 was used to account for the inter- and
intraspecies differences, and to account for the fact that the chronic
toxicity data base is incomplete.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
Data Considered for Establishing the RfD:
1) 3-Generation Reproduction - rat: Principal study - see previous
description; core grade supplementary
2) 2-Year Feeding (oncogenic) - rat: ChE NOEL=none; ChE LEL=0.05 mg/kg/day
(plasma ChE inhibition); core grade supplementary; interim report (Shell
Chemical, 1967a)
3) 2-Year Feeding - dog ChE NOEL=0.04 mg/kg/day; ChE LEL=0.4 mg/kg/day (RCB
and plasma ChE inhibition); core grade supplementary; interim report (Shell
Chemical, 1967b)
4) Teratology - rat: Embryotoxic NOEL=2.5 mg/kg/day; Embryotoxic LEL=5
mg/kg/day (decreased implantation sites); core grade supplementary;
preliminary report (Shell Chemical, 1965b)
5) Teratology - rabbit: Maternal NOEL=4 mg/kg/day; Maternal LEL=8 mg/kg/day
(salivation and tremors); no core grade (Shell Chemical, 1973)
Data Gap(s): Chronic Rat Feeding Study; Chronic Dog Feeding Study; Rat
Reproduction Study; Rat Teratology Study; Rabbit Teratology Study
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- Low
Data Base -- Low
RfD -- Low
The principal study is of low quality and is given a low confidence rating.
Additional studies are also of low quality and, therefore, the data base is
given a low confidence rating. Low confidence in the RfD follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Pesticide Data Evaluation Record and Registration Standard
Agency Work Group Review -- 08/19/1986, 09/02/1986
Verification Date -- 08/19/1986
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Bidrin
CASRN -- 141-66-2
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Bidrin
CASRN -- 141-66-2
This substance/agent has not undergone a complete evaluation and determination
under US EPA's IRIS program for evidence of human carcinogenic potential.
_VI. BIBLIOGRAPHY
Substance Name -- Bidrin
CASRN -- 141-66-2
Last Revised -- 11/01/1989
__VI.A. ORAL RfD REFERENCES
Shell Chemical Company. 1965a. MRID No. 00013446, 00066340. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1965b. MRID No. 00013447, 00141908. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1967a. MRID No. 00013563, 00013966. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1967b. MRID No. 00013564, 00013966. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1973. Accession No. 111367. Available from EPA.
Write to FOI, EPA, Washington, DC 20460.
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Bidrin
CASRN -- 141-66-2
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
11/01/1989 I.A. Principal study year corrected
11/01/1989 VI. Bibliography on-line
01/01/1992 IV. Regulatory actions updated
VIII. SYNONYMS
Substance Name -- Bidrin
CASRN -- 141-66-2
Last Revised -- 09/30/1987
141-66-2
BIDIRL
Bidrin
C 709
CARBICRON
CIBA 709
cis-2-DIMETHYLCARBAMOYL-1-METHYLVINYL DIMETHYLPHOSPHATE
cis-3-HYDROXY-N,N-DIMETHYLCROTONAMIDE
CROTONAMIDE, 3-HYDROXY-N,N-DIMETHYL-, cis-, DIMETHYL PHOSPHATE
CROTONAMIDE, 3-HYDROXY-N-N-DIMETHYL-, DIMETHYL PHOSPHATE, (E)-
DIAPADRIN
DICROTOFOS
DICROTOPHOS
3-(DIMETHOXYPHOSPHINYLOXY)-N,N-DIMETHYL-cis-CROTONAMIDE
3-(DIMETHOXYPHOSPHINYLOXY)-N,N DIMETHYLISOCROTONAMIDE
3-(DIMETHYLAMINO)-1-METHYL-3-OXO-1-PROPENYL DIMETHYL PHOSPHATE
DIMETHYLCARBAMOYL-1-METHYLVINYL DIMETHYLPHOSPHATE, cis-2-
2-DIMETHYL cis-2-DIMETHYL-CARBAMOYL-1-METHYLVINYL PHOSPHATE
EKTAFOS
ENT 24,482
ESTER
ESTER, (E)-
3-HYDROXYDIMETHYL CROTONAMIDE DIMETHYL PHOSPHATE
HYDROXY-N,N-DIMETHYLCROTONAMIDE, cis-3-
3-HYDROXY-N,N-DIMETHYL-cis-CROTONAMIDE DIMETHYL PHOSPHATE
O,O-DIMETHYL-O-(2-DIMETHYL-CARBAMOYL-1-METHYL-VINYL)PHOSPHAT
O,O-DIMETHYL-O-(1,4-DIMETHYL-3-OXO-4-AZA-PENT-1-ENYL)FOSFAAT
O,O-DIMETHYL-O-(1,4-DIMETHYL-3-OXO-4-AZA-PENT-1-ENYL)PHOSPHATE
O,O-DIMETHYL-O-(1-METHYL-2-N,N-DIMETHYL-CARBAMOYL)-VINYL-PHOSPHAT
O,O-DIMETHYL O-(N,N-DIMETHYLCARBAMOYL-1-METHYLVINYL) PHOSPHATE
O,O-DIMETIL-O-(1,4-DIMETIL-3-OXO-4-AZA-PENT-1-ENIL)-FOSFATO
PHOSPHATE DE DIMETHYLE ET DE 2-DIMETHYLCARBAMOYL 1-METHYL VINYLE
PHOSPHORIC ACID 3-(DIMETHYLAMINO)-1-METHYL-3-OXO-1-PROPENYL DIMETHYL
PHOSPHORIC ACID, DIMETHYL 1-METHYL-N,N-(DIMETHYLAMINO)-3-OXO-1-PROPENYL
SD 3562
SHELL SD-3562
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0211.HTM
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