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Benefin
CASRN 1861-40-1
Contents
0133
Benefin; CASRN 1861-40-1
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Benefin
File On-Line 03/31/1987
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 03/01/1988
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Benefin
CASRN -- 1861-40-1
Last Revised -- 03/01/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Depressed erythrocyte NOAEL: 25 mg/kg/day 100 1 3E-1
counts mg/kg/day
LOAEL: 125 mg/kg/day
Dog Chronic Oral
Bioassay
Eli Lilly and Co.,
1972
*Dose Conversion Factors & Assumptions: none
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
Eli Lilly and Company. 1972. MRID 00037678. Available from EPA. Write to
FOI, EPA, Washington, DC 20460.
Results of a chronic oral bioassay in dogs (four animals/sex/dose) established
a NOAEL of 25 mg/kg/day that was associated with a slight depression of
erythrocyte counts with no reduction in blood hemoglobin concentrations or
hematocrit, and a LOAEL of 125 mg/kg/day that was associated with increased
relative liver weights and depressed blood hemoglobin concentrations and
hematocrit. Additional studies support the choice of this effect level (i.e.,
25 mg/kg/day) as the basis of the RfD. Teratogenic effects were not seen at
doses up to 100 mg/kg/day in rabbits. Some reproductive problems were evident
in rats at approximately 250 mg/kg/day, but not at 50 mg/kg/day.
The British Crop Protection Council (BCPC, 1977) reported NOELs for rats
exposed orally to 1250 ppm/day (3 months) and greater than 500 ppm/day for
dogs administered benefin in capsules. No experimental details were given.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- The 100-fold uncertainty factor represents 10-fold dose reductions for
both the expected interhuman and interspecies variability to the toxicity of
this chemical in lieu of specific data.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
Data regarding developmental toxicity are not available in the published
literature.
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- Medium
Data Base -- Medium
RfD -- Medium
Confidence in the chosen study is medium because, although three doses were
tested and a good analysis was apparently performed, only four animals/
sex/dose were used. The data base rates a medium confidence; while not
extensive, it is supportive of the chosen effect level. Medium confidence in
the RfD follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Source Document -- U.S. EPA, 1984
The ADI in the 1984 Health and Environmental Effects Profile for Benefin
received an Agency review with the help of two external scientists.
Other EPA Documentation -- None
Agency Work Group Review -- 11/06/1985
Verification Date -- 11/06/1985
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Benefin
CASRN -- 1861-40-1
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Benefin
CASRN -- 1861-40-1
This substance/agent has not undergone a complete evaluation and determination
under US EPA's IRIS program for evidence of human carcinogenic potential.
_VI. BIBLIOGRAPHY
Substance Name -- Benefin
CASRN -- 1861-40-1
Last Revised -- 08/01/1989
__VI.A. ORAL RfD REFERENCES
BCPC (The British Crop Protection Council). 1977. Benefluralin. In:
Pesticide Manual, 5th ed. H.Martin and C.R. Worthing, Ed. BCPC Publications,
Worcestershire, England. p. 31.
Eli Lilly and Company. 1972. MRID 00037678. Available from EPA. Write to
FOI, EPA, Washington, DC 20460.
U.S. EPA. 1984. Health and Environmental Effects Profile for Benefin.
Prepared by the Office of Health and Environmental Assessment, Environmental
Criteria and Assessment Office, Cincinnati,OH for the Office of Solid Waste,
Washington, DC.
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Benefin
CASRN -- 1861-40-1
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
03/01/1988 I.A.1. Critical effect corrected
03/01/1988 I.A.4. Text revised
08/01/1989 VI. Bibliography on-line
01/01/1992 I.A.7. Secondary contact changed
01/01/1992 IV. Regulatory Action section on-line
VIII. SYNONYMS
Substance Name -- Benefin
CASRN -- 1861-40-1
Last Revised -- 03/31/1987
1861-40-1
BALAN
BALFIN
BANAFINE
BENALAN
BENEFEX
Benefin
BENFLURALIN
BETHRODINE
BINNELL
BLULAN
BONALAN
CARPIDOR
EL-110
EMBLEM
L 54521
N-BUTYL-2,6-DINITRO-N-ETHYL-4-TRIFLUOROMETHYLANILINE
N-BUTYL-N-ETHYL-2,6-DINITRO-4-(TRIFLUOROMETHYL)BENZENAMINE
N-BUTYL-N-ETHYL-alpha,alpha,alpha-TRIFLUORO-2,6-DINITRO-p-TOLUIDINE
QUILAN
p-TOLUIDINE, N-BUTYL-N-ETHYL-alpha,alpha,alpha-TRIFLUORO-2,6-DINITRO-
alpha,alpha,alpha-TRIFLUORO-2,6-DINITRO-N,N-ETHYLBUTYL-p-TOLUIDINE
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0133.HTM
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