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Ammonium sulfamate
CASRN 7773-06-0
Contents
0007
Ammonium sulfamate; CASRN 7773-06-0
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Ammonium sulfamate
File On-Line 01/31/1987
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 03/01/1991
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Ammonium sulfamate
CASRN -- 7773-06-0
Last Revised -- 03/01/1991
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Decrease in body NOEL: 214.3 mg/kg/day 1000 1 2E-1
weights mg/kg/day
LEL: 428.6 mg/kg/day
90-Day Rat Feeding
Study
Gupta et al., 1979
*Conversion Factors: Actual dose tested x 6/7 (6 days/week)
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
Gupta, B.N., R.N. Khanna and K.K. Datta. 1979. Toxicological studies of
ammonium sulfamate in rat after repeated oral administration. Toxicology.
13(1): 45-49.
Rats were administered ammonium sulfamate 6 days/week for 90 days at the
following dose levels: 0 (group 1), 100 (group 2), 250 (group 3) and 500
mg/kg/day (group 4) [Dose Conversion: 85.7, 214.3, and 428.6). No adverse
effects were observed in respect of appearance, behavior or survival of
animals. No significant difference in the body weights of rats was observed
except in case of adult rats (group 4) where the body weight was significantly
less than the controls after the end of 60 days. Results included gradually
reduced food intake and increased water intake. No significant change in
relative organ weights were noticed in all groups of rats.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 100 was to account for the inter- and
intraspecies differences. An additional UF of 10 was used to account for the
fact that the most sensitive toxicological endpoint has not been determined;
i.e. the lack of chronic exposure studies.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
Data Considered for Establishing the RfD
1) 90-Day Feeding - rat: Principal study - see previous description; no core
grade
2) 3-Generation Reproduction - rat: Reproduction NOEL=500 ppm (25 mg/kg/day);
no core grade (du Pont, 1966)
3) 105-Day Feeding - rat: NOEL=10,000 ppm (500 mg/kg/day) (1%); LEL=20,000
ppm (1000 mg/kg/day) (inhibited growth weights and induced a slight cathartic
action); no core grade (Rosen et al., 1965)
4) 6-Day Feeding - dog: Dogs fed 1 g of test material for 6 days; No systemic
effects were observed: no core grade (Ambrose, 1943)
Data Gap(s): Chronic Rat Feeding Study; Chronic Dog Feeding Study; Rat
Teratology Study; Rabbit Teratology
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- Medium
Data Base -- Low
RfD -- Low
The critical study is of fair quality and is given a medium confidence rating.
Since there are major data gaps existing for ammonium sulfamate, the data base
is given a low confidence rating. Low confidence in the RfD follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Pesticide Registration Files
Agency Work Group Review -- 06/24/1986, 07/20/1988
Verification Date -- 07/20/1988
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Ammonium sulfamate
CASRN -- 7773-06-0
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Ammonium sulfamate
CASRN -- 7773-06-0
This substance/agent has not undergone a complete evaluation and determination
under US EPA's IRIS program for evidence of human carcinogenic potential.
_VI. BIBLIOGRAPHY
Substance Name -- Ammonium sulfamate
CASRN -- 7773-06-0
Last Revised -- 03/01/1991
__VI.A. ORAL RfD REFERENCES
Ambrose, A.M. 1943. Studies on the physiological effects of sulfamic acid
and ammonium sulfamate. J. Ind. Hyg. Toxicol. 25(1): 26-28.
E.I. du Pont de Nemours & Company, Inc. 1966. MRID No. 00092903, 00143472,
00145269. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Gupta, B.N., R.N. Khanna and K.K. Datta. 1979. Toxicological studies of
ammonium sulfamate in rat after repeated oral administration. Toxicology.
13(1): 45-49.
Rosen, D.E., C.J. Krister, H. Sherman, E.F. Stula. 1965. Toxicity studies on
ammonium sulfamate. The Toxicologist. Fourth Ann. Meeting Society
of Toxicology, Williamsburg, Va. March 8-10.
__VI.B. INHALATION RfC REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Ammonium sulfamate
CASRN -- 7773-06-0
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
03/01/1988 I.A.1. Critical effect identified, LOAEL specified
03/01/1988 I.A.2. Principal study citation corrected
03/01/1988 I.A.2. Text revised
12/01/1988 I.A. Withdrawn; new RfD verified (in preparation)
01/01/1989 I.A. Oral RfD summary replaced; RfD changed
03/01/1991 I.A.4. Citations added
03/01/1991 III.A. Health Adviosry on-line
03/01/1991 VI. Bibliography on-line
06/01/1991 III.A.4. 70-kg 'child' corrected to 70-kg adult in assumptions
01/01/1992 IV. Regulatory actions updated
VIII. SYNONYMS
Substance Name -- Ammonium sulfamate
CASRN -- 7773-06-0
Last Revised -- 01/31/1987
7773-06-0
AMCIDE
AMICIDE
AMMAT
AMMATE
AMMATE X
AMMONIUM AMIDOSULFONATE
AMMONIUM AMIDOSULPHATE
AMMONIUMSALZ DER AMIDOSULFONSAURE
Ammonium Sulfamate
AMMONIUM SULPHAMATE
AMS
IKURIN
MONOAMMONIUM SULFAMATE
NA 9089
SULFAMATE, AMMONIUM
SULFAMIC ACID, MONOAMMONIUM SALT
SULFAMINSAURE
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0007.HTM
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