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Related Background Documents

These background documents are available online:

Reference Dose (RfD): Description and Use in Health Risk Assessments

EPA Approach for Assessing the Risks Associated with Chronic Exposures to Carcinogens

Proposed Guidelines for Carcinogen Risk Assessment

The following documents, though not available online, are available from the U.S. EPA Risk Information Hotline at telephone 1-513-569-7254, fax 1-513-569-7159, email RIH.IRIS@epamail.epa.gov and/or the National Technical Information Service Exit the EPA's Web Site.
EPA Reference Citations
U.S. EPA. 1987a. Risk Assessment Guidelines of 1986 (EPA/600/8-87/045, dated August 1987)

U.S. EPA. 1988a. Recommendations for and Documentation of Biological Values for use in Risk Assessment. EPA 600/6-87/008, NTIS PB88-179874/AS, February 1988.

U.S. EPA. 1991. Guidelines for Developmental Toxicity Risk Assessment, dated December 5, 1991. Fed. Reg. 56, No.234: 63798-63826.

U.S. EPA. 1994a. Interim Policy for Particle Size and Limit Concentration Issues in Inhalation Toxicity: Notice of Availability, dated October 26, 1994. Fed. Reg. 59, No.206: 53799.

U.S. EPA. 1994b. Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry, EPA/600/8-90/066F, dated October 1994.

U.S. EPA. 1995a. Guidance on Risk Characterization, memorandum of the Administrator, Carol Browner, dated March 21, 1995.

U.S. EPA. 1995b. (proposed) Guidelines for Neurotoxicity Risk Assessment, dated October 4, 1995. Fed. Reg. 60, No. 192: 52032-52056.

U.S. EPA. 1995c. Use of the Benchmark Dose Approach in Health Risk Assessment, EPA/630/R-94/007, dated February 1995.

U.S. EPA. 1996a. Proposed Guidelines for Carcinogen Risk Assessment: Notice dated April 23, 1996. Fed. Reg. 61, No. 79: 17960-18011.

U.S. EPA, 1996b. Guidelines for Reproductive Toxicity Risk Assessment: Notice dated October 31, 1996. Fed. Reg. 61, No. 212: 56274-56322.

See also these online IRIS documents:

Introduction to IRIS

Glossary of Risk Assessment-Related Terms

List of Acronyms and Abbreviations


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Last updated: 20 February 1998
URL: http:/www.epa.gov/iris/BACKGRD2.HTM.HTM