In order to prepare 3-methylcyclohexanone from 2-cyclohexenone, a methyl group must be introduced into the b-carbon of the a-b-unsaturated ketone. The conjugate addition of an alkyl group is most readily accomplished using a dialkylcopper lithium reagent.
The target molecule is simply the oxime of 2-cyclohexenone. Oximes can be prepared from the parent ketone or aldehyde by reaction with NH2OH.
In order to prepare cyclohexene from 2-cyclohexenone, the carbonyl group must be reduced to the hydrocarbon, without reducing the double bond. This is readily accomplished using the Wolff-Kishner reduction (H2NNH2 in the presence of KOH); the Clemmensen reduction will also work (Zn(Hg)/H3O+).
In order to prepare 3-phenylcyclohexanone from 2-cyclohexenone, a phenyl group must be introduced into the b-carbon of the a-b-unsaturated ketone. The conjugate addition of an aryl group is most readily accomplished using a diarylcopper lithium reagent.
In order to prepare 3-phenylcyclohexanone from 2-cyclohexenone, a phenyl group must be introduced into the b-carbon of the a-b-unsaturated ketone. The conjugate addition of an aryl group is most readily accomplished using a diarylcopper lithium reagent.
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