In order to prepare 1-butanol from butanoic acid, you must simply reduce the carbonyl group to the alkane. This can be done readily using either BH3/THF/H3O+ or LiAlH4.
The target molecule is 1-bromobutane. Alkyl bromides can be prepared from the corresponding alcohols by reaction with PBr3. The required alcohol has the same carbon skeleton as the starting material, butanoic acid; therefore, the desired product can be prepared by simple reduction of the acid to the alcohol using either BH3/THF/H3O+ or LiAlH4, followed by bromination with PBr3.
The target molecule is pentanoic acid. The final product has one additional carbon in the parent chain and is a carboxylic acid. We can add one carbon and synthesize carboxylic acids by the reaction of a Grignard reagent with carbon dioxide. The required Grignard reagent has the same carbon skeleton as the starting material, butanoic acid; therefore, the desired product can be prepared by simple reduction of the acid to the alcohol using either BH3/THF/H3O+ or LiAlH4, followed by bromination with PBr3, conversion to a Grignard reagent and carboxylation.
In order to prepare 1-butanol from butanoic acid, you must simply reduce the carbonyl group to the alkane. This can be done readily using either BH3/THF/H3O+ or LiAlH4.
The target molecule is 1-bromobutane. Alkyl bromides can be prepared from the corresponding alcohols by reaction with PBr3. The required alcohol has the same carbon skeleton as the starting material, butanoic acid; therefore, the desired product can be prepared by simple reduction of the acid to the alcohol using either BH3/THF/H3O+ or LiAlH4, followed by bromination with PBr3.
The target molecule is pentanoic acid. The final product has one additional carbon in the parent chain and is a carboxylic acid. We can add one carbon and synthesize carboxylic acids by the reaction of a Grignard reagent with carbon dioxide. The required Grignard reagent has the same carbon skeleton as the starting material, butanoic acid; therefore, the desired product can be prepared by simple reduction of the acid to the alcohol using either BH3/THF/H3O+ or LiAlH4, followed by bromination with PBr3, conversion to a Grignard reagent and carboxylation.