Dr.
Milan Mrksich
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ABSTRACT:
This talk will outline an opportunity in the broad field of biochips for developing
tailored substrates that combine advantages in immobilized format assays and
detection by MALDI-TOF mass spectrometry. The approach is based on self-assembled
monolayers that present proteins, peptides and carbohydrates as platforms for
identifying enzymatic and protein-binding activities. The monolayers have
the
important property that they are inert to non-specific adsorption of proteins,
and therefore can provide quantitative measurement of biological activities.
A further benefit of the monolayer substrates is that they are well-suited for
MALDI-TOF MS and therefore can be analyzed with label-free methods. The
talk
will provide examples pertaining to assays of enzymatic activity, identification
of unknown protein targets from on-chip affinity interactions, and high throughput
chemical screening in drug discovery.
BIOGRAPHY:
Milan Mrksich is a native of Chicago and attended the University of Illinois
as an undergrate. Following graduate work at Caltech and a postdoctoral
appointment at Harvard, Dr. Mrksich began his independent position in 1996
in the Chemistry
Department at the University of Chicago. Dr. Mrksich is currently Professor
of Chemistry and a founding member of the Institute of Biophysical Dynamics.
His work to develop surface chemistries for a broad range of biological
problems is described in more than 100 publications. He serves as an advisory
board
member to several companies and government agencies, including the DARPA Defense
Sciences Research Council and the Board of Governors of Argonne National Laboratory.
His contributions have been recognized with several awards, including
the Cope Scholar Award, the TR100 Young Innovator Award and the Searle Scholar
Award.
Meeting Time: Social hour at 4:30 PM, Presentation at 5:30 PM, Dinner at 6:30
Cost: $10. No cost to students with ID cards. Membership in CMSDG is not necessary to attend this meeting, but we would welcome our guests to join CMSDG for $10 for the year. (No hard sell — join if you like.)
Map and directions to the College of Pharmacy