Where:

Mings Grand Palace,
5572 Grand Avenue (Rte. 132)
Gurnee, Illinois,   (847)662-2929

ABSTRACT:  

Combinatorial chemistry is becoming a very useful technique for quickly determining lead candidates for new drugs. Combinatorial library synthesis allows large numbers of compounds to be synthesized in a relatively short period of time. The generation of a peptide library composed of over 100,000 different peptide species is easily accomplished in a matter of days. Thus, combinatorial libraries hold huge promise for the rapid discovery of new pharmaceuticals. The challenge is how to select and analyze the library components that have the desired properties from the extremely complex mixture of peptides. This becomes increasingly difficult as the size of the library increases.

There are two key steps involved in the analysis of any combinatorial library. The first involves the ability to select and separate the compounds with the desired properties from the rest of the library components. We are accomplishing this by using various separation techniques, including high-performance liquid chromatography (HPLC) and immunoaffinity separations. The second step in the analysis involves determining the identity of the selected compounds. Mass spectrometry is an ideal method of analysis for these libraries, since the structural information that mass spectrometry can provide allows the identity of a selected component to be established from a complex mixture. Using tandem mass spectrometry we have successfully analyzed libraries of over 150,000 components and determined the identity of the best lead candidates. We are currently applying these techniques to identify antagonists for several growth factors, including Vascular Endothelial Growth Factor (VEGF), that play a role in cancer.

Meeting Time:   Social hour at 5:30 PM, Dinner at 6:30 PM, Talk begins at 7:30

Cost:   $25

Registration:   Please respond by Friday, March 1
Call Qin Ji at 847-937-5786 or   register on line !!

or e-mail to: Qin.Ji@abbott.com with name, organization, number of people, and phone.
Let us know when you register if you need a special meal.

Directions to Mings:

From the north or south, via the Tri-State Tollway, (I-94):

Take the Tri-State to Grand Avenue (Rt. 132) in Gurnee (North of Chicago, west of Waukegan). Exit east to the first stoplight, Dilley's Road. Mings is on the north-east corner in front of the Hampton Inn.